Poor relevance of a lymphocyte proliferation assay in lamotrigine‐induced <scp>S</scp>tevens–<scp>J</scp>ohnson syndrome or toxic epidermal necrolysis

Abstract

With the largest number of LTT performed in patients with SJS or TEN to a single drug, we confirmed that reactive cells are rarely detected in these reactions. Poor reactivity did not seem related to T-reg. Other in vitro assays than those testing proliferation should be evaluated, before raising the hypothesis that specific cells disappeared by undergoing apoptosis during the reaction.