Concepedia

A very efficient, copper-free palladium catalyst for the Sonogashira reaction with aryl halides

Karine Heuzé, Didier Astruc

Chemical Communications · 2003 · 118 citations · 16 references

DOI

Concepts

Abstract

The new complex [Pd[t-Bu2PCH2N(CH2Ph)CH2P t-Bu2](OAc)2] is a very efficient catalyst for the Sonogashira cross-coupling reaction of aryl halides with acetylenes at room temperature, without co-catalyst.

References

16

A convenient synthesis of acetylenes: catalytic substitutions of acetylenic hydrogen with bromoalkenes, iodoarenes and bromopyridines

Kenkichi Sonogashira, Yasuo Tohda, Nobue Hagihara · Tetrahedron Letters · 1975 · 5.1K citations

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Acetylenic Coupling: A Powerful Tool in Molecular Construction

Peter Siemsen, R. C. Livingston, François Diederich · Angewandte Chemie International Edition · 2000 · 1.5K citations

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Layered Double Hydroxide Supported Nanopalladium Catalyst for Heck-, Suzuki-, Sonogashira-, and Stille-Type Coupling Reactions of Chloroarenes

B. M. Choudary, Sateesh Madhi, Naidu S. Chowdari et al. · Journal of the American Chemical Society · 2002 · 697 citations

, , +17

Pd(PhCN)<sub>2</sub>Cl<sub>2</sub>/P(<i>t</i>-Bu)<sub>3</sub>:  A Versatile Catalyst for Sonogashira Reactions of Aryl Bromides at Room Temperature

Thomas Hundertmark, Adam F. Littke, Stephen L. Buchwald et al. · Organic Letters · 2000 · 427 citations

, , +9

A Copper-Free Sonogashira Coupling Reaction in Ionic Liquids and Its Application to a Microflow System for Efficient Catalyst Recycling

Takahide Fukuyama, Masutaka Shinmen, Satoshi Nishitani et al. · Organic Letters · 2002 · 375 citations

, , +16