The Journal of Clinical Endocrinology & Metabolism · 1941 · 49 citations · 0 references
MedicineEndocrinologyAndrologyReproductive EndocrinologyReproductive MedicineAndrogen DeficiencyAndrogen PhysiologyGonadal HormonesMale Reproductive EndocrinologyTesticular DisordersTesticular FunctionAdrenal Androgen DisordersAndrogen MetabolitesAndrogen PharmacologyEndocrine FailureTabletsTesticular FailureTesticular HormonesTestosterone Therapy
NINETEEN MEN have been treated with oral methyl testosterone for periods ranging from two weeks to ten months. Of these, 11 have been treated for 4 months or more and 6 for 2 months or less. There were 11 cases of testicular deficiency : 9 of eunuchoidism, 1 of infantilism and 1 of a suprasellar cyst. In addition, there were 7 cases of functional impotence, 1 of which had associated severe Grave's disease. The remaining case was of pseudohermaphrodism. Androgen assays were normal in all of the 7 cases treated only for impotence. There was no clinical evidence of endocrine disorder in any of these except in the one with hyperthyroidism. In none was the impotence improved by treatment. The dose of methyl testosterone (1) has varied from 25 to 300 mg. per day in 25 mg. tablets.