Collagen‐Derived Biomaterials in Bone and Cartilage Repair

Abstract

Abstract Summary: We have analyzed a number of collagen‐derived biomaterials for the matrix‐ induced and assisted bone and cartilage tissue regeneration. These include the Small intestine submuosa (SIS) Restor ™, ACI‐Maix collagen membrane, Chondro‐ Gide collagen membrane, Permacol collagen Ossix and lycoll collagen membrane and five types of collagen‐based marine sponge skeletons. Certain characteristics of different scaffold materials with comparable chemical composition may vary significantly. This variation may have a relevant impact on the suitability of the scaffolds for bone and cartilage regeneration. It suggests that the ACI‐Maix® membrane is the best available collagen‐derived material for an MACI®/MACT® application. In addition, the study of marine sponge indicates that the collagenous fibre skeleton of marine sponges provides a suitable bioscaffold for bone regeneration, as it supports the adhesion, migration and proliferation of osteoblasts in vitro .