Synthesis of Cyclic Peptides through an Intramolecular Amide Bond Rearrangement

Abstract

Latent thioesters: Reverse native chemical ligation followed by intramolecular trans-thioesterification and acyl transfer can rearrange linear peptides into biologically active cyclic products. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.