A Preconditioning Nerve Lesion Inhibits Mechanical Pain Hypersensitivity following Subsequent Neuropathic Injury

Abstract

These results suggest that prior exposure to a mild nerve lesion protects against adverse effects of subsequent neuropathic injury, and that this conditioning-induced inhibition of pain hypersensitivity is not dependent on neuroinflammation in DRGs and spinal cord. Identifying the underlying mechanisms may have important implications for the understanding of neuropathic pain due to nerve injury.