Genetics · 2014 · 12 citations · 23 references
Life SciencesCell BiologyGeneticsApoptosisCell DivisionGametogenesisApoptosis RegulationCell-cycle CheckpointsDna Damage SignalingDna Damage-induced ApoptosisGerm Cell ApoptosisProgrammed Cell DeathC. Elegans Developmental ModelsDna Damage Checkpoint ActivationDna Damage InductionDna Damage-induced Germ Cell DeathMeiotic Checkpoint ControlMeiotic CheckpointsMeiotic Dna Damage ResponseMeiotic Recombination Checkpoints
In Caenorhabditis elegans, germline apoptosis is promoted by egl-1 and ced-13 in response to meiotic checkpoint activation. We report that the requirement for these two factors depends on which checkpoints are active. We also identify a regulatory region of egl-1 required to inhibit germline apoptosis in response to DNA damage incurred during meiotic recombination.
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