Pharmacological evaluation of oral hypoglycemic and antidiabetic effects of fresh leaves ethanol extract of morinda lucida benth. in normal and alloxan- induced diabetic rats

Abstract

In the present study, 50 – 400 mg/kg of body weight/day of 50% ethanolextract of the fresh leaves of Morinda lucida Benth. (MLE) was investigatedfor its hypoglycemic and antidiabetic effects in adult normal and alloxaninduced diabetic male rats for 7 days. Acute oral toxicity study of MLE at the limit dose of 2000 mg/kg of body weight using Up-and-Down Procedure on statistical program, AOT425Pgm, was also conducted. Results showed that MLE significantly (p