FXR Deficiency Causes Reduced Atherosclerosis in<i>Ldlr</i>^−/−Mice

Abstract

FXR deficiency in male, but not female, Ldlr-/- mice results in a reduction in the size of atherosclerotic lesions in the aorta. The reduction in atherosclerosis may result from a decrease in plasma low-density lipoprotein cholesterol, coupled with reduced expression of CD36 in macrophages of DKO mice.