Capsaicin-sensitive vagal afferents modulate posttranscriptional regulation of the rat Na⁺/glucose cotransporter SGLT1

Abstract

SGLT1 transcription is independent of the vagus. However, dissociation of the protein rhythm from the underlying mRNA signal by vagotomy suggests the vagus may be involved in posttranscriptional regulation of SGLT1 in an RS1 independent pathway. Disruption following afferent ablation by capsaicin suggests this limb is specifically necessary.