Inflammatory reaction after intrasynovial injection of microcrystalline adrenocorticosteroid esters

Abstract

Abstract Injection of commercially available microcrystalline adrenocorticosteroid esters into normal canine joints was ac‐companied by a leukocyte‐rich exudative response, roughly proportional to the dose injected. No tenderness or evidence of pain was noted. Injection of these preparations into normal human joints often induced similar reactions which were sometimes painful. The response varied with the preparation employed and in the case of hydrocortisone acetate, with the manufacturer of the drug. The possible injurious effects of this relatively painless inflammatory response are discussed.