Enantioselective Organocatalytic Hydrophosphination of α,β‐Unsaturated Aldehydes

Abstract

Keeping it simple: Optically active phosphine derivatives can be obtained in high yields and in up to 99 % ee by using simple chiral amines to catalyze the hydrophosphination of α,β-unsaturated aldehydes (see scheme, green sphere=chiral group). The synthetic utility of this highly chemo- and enantioselective transformation was exemplified by the one-pot asymmetric synthesis of β-phosphine oxide acids. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2007/z700916_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.