Subepithelial Myofibroblasts Express Cyclooxygenase-2 in Colorectal Tubular Adenomas

Abstract

These results show that increased COX-2 expression in sporadic adenoma of the colon is common and is localized specifically to subepithelial intestinal myofibroblasts. These findings further support the hypothesis that myofibroblasts are important target cells for NSAID-mediated chemoprevention of colorectal cancer.