Biological Activities Assessment of<i>Centella asiatica</i>(Linn.)

Abstract

Biological activities of Centella asiatica were determined as cytotoxic activity–LD50 = 1926 μg.mL−1 using Artemia salina; mild insecticidal activity (40% mortality) against Rhyzopertha dominica; no activity against Tribolium castaneum and Callosobruchus analis; phytotoxicity (70% growth regulation at 1,000 μg.mL−1 and 10% growth regulation at 10 μg.mL−1) against Lemna minor. Mild antibacterial and antifungal activities were noted against Bacillus subtilis, Pseudomonas aeruginosa, and Candida albicans, while no activity was noted against Staphylococcus aureus and E. coli. Antioxidant performance was comparable to ascorbic acid, and analgesic and anti-inflammatory activities comparable with aspirin at 100 mg.kg−1b.w.