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Lack of polymorphism of the conversion of losartan to its active metabolite E-3174 in extensive and poor metabolizers of debrisoquine (cytochrome P450 2D6) and mephenytoin (cytochrome P450 2C19)

Medicinal ChemistryBiochemistryMedicineNatural SciencesHerb-drug InteractionMetabolomic ProfilingToxicologyMetabolomicsCytochrome P450 2D6PharmacologyActive Metabolite E-3174Drug DiscoveryCytochrome P450 2C19Drug Analysis