Haemostasis · 2009 · 14 citations · 0 references
MedicineHematologyPharmacologyClinical PharmacologyHemostasisPharmacodynamicsAnticoagulant TherapyAnticoagulation TherapyAntithrombotic TherapyPlatelet PhysiologyThrombosisThrombosis PreventionAnimal Model AnalysisAnimal Model EvaluationAnimal Model PharmacologyExperimental Model TestingHeparin AnticoagulationHeparin-mediated AnticoagulationTherapeutic Anticoagulation
The feasibility of employing the rat as an experimental model for investigation of full-dose heparin anticoagulation was assessed. Striking similarities were found to exist between rats and humans regarding baseline-activated partial thromboplastin time (APTT) values, and dosage per kilogram of heparin required to produce an APTT value of 1 1/2-3 times normal, the clinical definition of full-dose heparinization. Based upon these similarities, it appears that the rat can effectively serve as an experimental model for investigating the effects of heparin in humans.