Cancer · 1991 · 31 citations · 14 references
MedicineSurgeryUrologyGenitourinary OncologyMetastasisUrologic OncologyKidney CancerMetastatic Urologic CancerRenal NeoplasmsSquamous Cell CarcinomaUpper Urinary Tract Cancer SurgeryUrothelial CarcinomaRenal CalculiSquamous Cell Carcinoma HistopathologyUpper Tract Urothelial Carcinoma SurgeryUpper Tract Urothelial Carcinoma TherapyUpper Urinary Tract TumorsUpper Urinary Tract Urothelial Carcinoma DiagnosisUpper Urinary Tract Urothelial Carcinoma SurgeryUrinary Calculi
Forty-six patients with primary squamous cell carcinoma of the upper urinary tract treated over a 44-year period were studied. The lack of characteristic presentation caused delay in diagnosis. Associated urinary calculi were found in only five (11%) of the patients. Almost all of the tumors were histologically high grade; at surgery, 84% of the tumors were locally advanced or metastatic. Prognosis is poor independent of treatment; the overall 24-month survival rate was 22%. Comparison with a previous study of renal pelvic transitional cell carcinoma indicates that these two forms of urothelial neoplasm are biologically different.
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