Increased Cholesterol Deposition, Expression of Scavenger Receptors, and Response to Chemotactic Factors in <i>Abca1</i> -Deficient Macrophages

Abstract

Our studies indicate that the absence of ABCA1 leads to significant changes in the morphology, properties, and functional activities of macrophages. These changes, together with the proinflammatory condition present in ABCA1-deficient mice and increased reactivity of macrophages to chemotactic factors, play a key role in the development and progression of atherosclerosis.