Selective and Unusual Fluoride Ion Complexation by A Steroidal Receptor Using OH...F^- and CH...F^- Interactions: A New Motif for Anion Coordination?

Abstract

[structure: see text] A novel cholaphane has been synthesized from a naturally occurring bile acid in just two steps. It has an ability to bind two fluoride ions selectively utilizing the glycolate motif in chloroform. This "inside-out" cyclodextrin analogue encapsulates fluoride through O-H...F(-) and C-H...F(-) interaction.