Acta Medica Scandinavica · 1973 · 96 citations · 12 references
MedicinePharmacologyPharmacotherapyCardiovascular PharmacotherapyClinical PharmacologyPharmacodynamicsBlood Pressure ControlBlood Pressure ManagementBlood Pressure RegulationHypertension ManagementHypertension PharmacotherapyRenal PharmacologyAntihypertensive Drug TherapyAntihypertensive PharmacologyBlood PressurePlasma Renin ActivityRenin-angiotensin-aldosterone System Blockade
Abstract In 17 patients with essential hypertension on chlorthalidone treatment alprenolol was given in double‐blind crossover trial. The effect on blood pressure (BP), plasma renin activity (PRA) and blood volume was studied. During chlorthalidone treatment PRA was increased and blood volume decreased. Alprenolol induced a significant decrease in systolic and diastolic BP and PRA. The alprenolol‐induced decreases in BP and PRA were significantly correlated. Alprenolol did not influence the decreased blood volume during chlorthalidone treatment. The effect of β‐adrenergic blocking agents on the renin release from the kidney and its possible role in the hypotensive effect of these agents are discussed.
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Use of Propranolol (Inderal) in Treatment of Hypertension
B. N. C. Prichard, P. M. C. Gillam · BMJ · 1964 · 417 citations · Full text
The Paradox of Beta-Adrenergic Blockade in Hypertension
Edward D. Fröhlich, Robert C. Tarazi, Harriet P. Dustan et al. · Circulation · 1968 · 267 citations · Full text
Adrenergic Receptor Mediation of Renin Secretion
Nathaniel Winer, Deenbandhu S. Chokshi, Myung S. Yoon et al. · The Journal of Clinical Endocrinology & Metabolism · 1969 · 241 citations
Medicine, Pharmacology, Physiology +15
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Robert C. Tarazi, Harriet P. Dustan, Edward D. Fröhlich · Circulation · 1970 · 216 citations · Full text