Perioperative Complications of Recombinant Human Bone Morphogenetic Protein-2 on an Absorbable Collagen Sponge Versus Iliac Crest Bone Graft for Posterior Cervical Arthrodesis

Abstract

The higher incidence of posterior cervical wound complications in the rhBMP-2/ACS group, although not statistically significant, may be related to an inflammatory response to rhBMP-2. This potential risk must be weighed against the elimination of donor-site complications associated with ICBG harvesting, and considered in light of ultimate clinical outcome. Additional studies are needed to clarify this issue, as well as to determine optimal dosing and carrier for usage in the posterior cervical spine.