The gentamicin antibiotics. Part II. Separation and degradation of the gentamicin C components. The purpurosamines, a new class of naturally occurring 2,6-diaminomonosaccharides

Abstract

Separation of the gentamicin C components by column chromatography and subsequent mercaptolysis of their per-N-acetyl derivatives has permitted the isolation of derivatives of three new amino-sugars named purpurosamine A, B and C corresponding to gentamicins C1, C2a, and C1a respectively. The purpurosamines are shown to be members of the 2,6-diamino-2,3,4,6-tetradeoxyhexose family, a new class of naturally occurring monosaccharides.