Concepedia

Publication | Closed Access

High degree of inter-clade cross-reactivity of HIV-1-specific T cell responses at the single peptide level

DOI

27

Citations

0

References

2005

Year

Xu G. Yu, Mathias Lichterfeld, Beth Perkins, Elizabeth T. Kalife, Stanley K. Mui, Jianping Chen, Michael L. Cheng, Wenzhen Kang, Galit Alter, Christian Brander,
AIDS

Abstract

Viral epitopes within regions of low HIV-1 clade B diversity and high inter-clade homology can be recognized in the clade A, B and C variants and indicate a wide degree of cross-isolate and cross-clade recognition by HIV-1-specific T cells. These regions may therefore be of particular relevance for the design of HIV-1 vaccines.