Artificial Receptors Designed for Intracellular Delivery of Anionic Phosphate Derivatives

Abstract

A new intracellular delivery method for anionic phosphate derivatives using the Dpa–ZnII-based metalloreceptor as a carrier vector was developed. This method enables rapid intracellular delivery of phosphorylated peptides and phosphorylated small organic molecules without the need for laborious modification associated with prodrugs. This is of critical importance in a variety of research areas such as cell biology and medicinal chemistry. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2268/2008/z700627_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.