Low‐dose lansoprazole and clarithromycin plus metronidazole vs. full‐dose lansoprazole and clarithromycin plus amoxicillin for eradication of <i>Helicobacter pylori</i> infection

Abstract

In this open, randomized controlled trial, eradication of H. pylori by low-dose lansoprazole and clarithromycin plus metronidazole was higher with significantly less side-effects than by full-dose lansoprazole and clarithromycin plus amoxicillin. This finding may be related to the stronger synergism of clarithromycin plus metronidazole, even at lower doses, than of clarithromycin plus amoxicillin. Considering the lower cost as well, LCM should be preferred to LCA in the eradication of H. pylori.