One-pot chemoenzymatic syntheses of enantiomerically-enriched O-acetyl cyanohydrins from aldehydes in ionic liquid

Abstract

A practical and efficient method for the synthesis of optically active O-acetyl cyanohydrins via one-pot lipase-catalyzed kinetic resolution of the in situ generated racemic cyanohydrins or O-acetyl cyanohydrins using an ionic liquid as both reaction media and promoter has been described.