Multivalent Manno‐Glyconanoparticles Inhibit DC‐SIGN‐Mediated HIV‐1 Trans‐Infection of Human T Cells

Abstract

Gold simplifies matters: Gold manno-glyconanoparticles displaying different densities of linear and branched mannose oligosaccharides acted as inhibitors of DC-SIGN-mediated HIV trans-infection of human activated peripheral blood mononuclear cells. Presentation of simple linear di-, tri-, and tetraoligosaccharides on the nanoclusters resulted in efficiencies similar to those observed for complex branched penta- and heptamannosides. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.