Association between DRD2/ANKK1 Taq1A genotypes, depression and smoking cessation with nicotine replacement therapy

Abstract

Those having a Taq1A variant allele and a history of depression are likely to experience particular difficulty when trying to stop smoking and may require treatment other than standard doses of nicotine replacement. This finding might explain previous conflicting results for Taq1A and smoking cessation in studies where depression history was not measured, and may help to explain the underlying link between depression and smoking.