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A single 8,5′-cyclo-2′-deoxyadenosine lesion in a TATA box prevents binding of the TATA binding protein and strongly reduces transcription in vivo

Single 8,5′-Cyclo-2′-deoxyadenosine LesionTranscriptional RegulationSignal TransductionProtein ExpressionMedicineNatural SciencesTranscription RegulationMolecular BiologyGene RegulationReduces TranscriptionGene ExpressionEpigenetic RegulationCell BiologyRna ProcessingTata Binding Protein