Clinicopathological Analysis of Papillary Thyroid Cancer with<i>PIK3CA</i>Alterations in a Middle Eastern Population

Abstract

A higher incidence of PIK3CA alterations and the possible synergistic effect of PIK3CA alterations and BRAF mutations suggest their major role in Middle Eastern PTC tumorigenesis and argue for therapeutic targeting of PI3K/AKT and MAPK pathways.