Determination of Thiopurine Methyltransferase Genotype or Phenotype Optimizes Initial Dosing of Azathioprine for the Treatment of Crohn’s Disease

Abstract

patients with Crohn's disease and normal TPMT activity who were started on high-dose AZA (2-2.5mg /kg/d) and patients with intermediate enzyme activity who were started on reduced doses of AZA did not develop acute leukopenia.