One-year reduction and longitudinal analysis of carotid intima-media thickness associated with colestipol/niacin therapy.

Abstract

Reduction of carotid IMT was found with aggressive lipid-lowering therapy. Ultrasound measures of IMT offer a noninvasive and precise measure of early carotid atherosclerosis that will decrease sample size requirements, potentially decrease dropout rates, and widen the study population of antiatherosclerotic clinical trials.