Fundamental Limitations of [ ¹⁸ F]2-Deoxy-2-Fluoro- <scp>d</scp> -Glucose for Assessing Myocardial Glucose Uptake

Abstract

The uptake and retention of FDG in heart muscle is linearly related to glucose utilization only under steady-state conditions. Addition of insulin or of competing substrates changes the relation between uptake of the glucose tracer and FDG. These observations preclude the determination of absolute rates of myocardial glucose uptake by the tracer analog method under non-steady-state conditions.