Regioselective Nucleophilic Opening of <i>erythro</i>-and <i>threo</i>-2,3-Epoxy Alcohols

Abstract

Abstract The epoxide opening reactions of erythro and threo epoxy alcohols with a variety of nucleophiles, both in the presence and absence of Ti(OiPr)4, were examined. In general, opening of threo epoxy alcohols proceeded faster and with higher selectivity than the same reaction with the corresponding erythro isomers.