Concepedia

Biphasic Effect of HMG-CoA Reductase Inhibitor, Pitavastatin, on Vascular Endothelial Cells and Angiogenesis

M. Katsumoto, Tetsuji Shingu, R. Kuwashima, Atsunori Nakata, Shuichi Nomura, Kazuaki Chayama

Circulation Journal · 2005 · 63 citations · 49 references

DOIFull text

Open access

Abstract

Pitavastatin has a biphasic effect on HMVECs and on angiogenesis through at least 2 different pathways that include the mevalonate pathway.

References

49

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

Anders Olsson, John J.V. McMurray, G Thorgeirsson et al. · The Lancet · 1994 · 8.5K citations

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The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

Frank M. Sacks, Marc A. Pfeffer, Lemuel A. Moyé et al. · New England Journal of Medicine · 1996 · 7.5K citations · Full text

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

James Shepherd, Stuart M. Cobbe, Ian Ford et al. · New England Journal of Medicine · 1995 · 7.5K citations · Full text

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

New England Journal of Medicine · 1998 · 5.3K citations · Full text

PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA

J Ames S Hepherd, S Tuart M. C Obbe, I An F Ord et al. · 1995 · 3.5K citations

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