Prostaglandin E₂ is an enhancer of interleukin‐1β–induced expression of membrane‐associated prostaglandin E synthase in rheumatoid synovial fibroblasts

Abstract

Enhancement of mPGES expression by PGE(2) via the EP2/EP4 receptors with an increase in cAMP may play an important role in articular inflammation in patients with RA. It also seems that cyclooxygenase 2 (COX-2) inhibitors decrease PGE(2) production not only by direct inhibition of COX-2, but also by reducing mPGES expression in activated RASFs.