Bioscience Biotechnology and Biochemistry · 1994 · 23 citations · 0 references
PharmacyEntomologyMedicinal ChemistryDrug DiscoverySynthetic Medicinal ChemistryAnthelmintic PharmacologyAntiparasitic AgentsAntiparasitic PharmacologyPeptide Bond ChemistryPeptide ChemistryAnthelmintic AgentsAnthelmintic Drug DevelopmentAnthelmintic Drug TherapyAnthelmintic TreatmentDrug Discovery For AnthelminticsNatural Product Total SynthesisSynthetic Antiparasitic CompoundsTotal Synthesis-derived Analogues
The anthelmintic cyclooctadepsipeptide PF1022A and its antipode were synthesized starting from l-Nα-Boc-leucine (for PF1022A), d-Nα-Boc-leucine (for the antipode), l-lactic acid, and l-phenyllactic acid using Mitsunobu reaction and/or the DCC/HOBt method. The antipode had no anthelmintic efficacy.