Publication | Closed Access
Syntheses of Optically Active Verrucarinic Acid. 40th Communication on Verrucarins and Roridins
63
Citations
28
References
1983
Year
Verrucarinic AcidBiosynthesisBioorganic ChemistryDerivativesBiochemistryEngineeringNatural SciencesPig Liver EsteraseOrganic ChemistrySynthetic ChemistryStereoselective SynthesisChemical BiologyPharmacologyPharmaceutical ChemistrySharpless EpoxidationEnantioselective SynthesisBiomolecular EngineeringNatural Product Synthesis
Abstract Three syntheses of (2 S , 3 R )‐2,5‐dihydroxy‐3‐methylpentanoic acid (verrucarinic acid) and its derivatives suitably protected for the further transformation to macrocyclic trichothecenes are described. These involve an enantioselective ester hydrolysis by pig liver esterase, a Sharpless epoxidation and an asymmetric hydroboration.
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