Glibenclamide does not abolish the protective effect of preconditioning on stunning in the isolated perfused rat heart

Abstract

Thus, although inhibition of KATP channels accelerates high energy phosphate depletion during the preconditioning period, this does not result in accentuation of the ionic derangements during a subsequent sustained period of ischaemia and does not abolish the protective effect of preconditioning on stunning in the isolated rat heart.