Derivatized Polysaccharides: Preparation, Characterization, and Application as Bioadhesive Polymer for Drug Delivery

Abstract

Derivatization of a natural polysaccharide, tamarind seed polysaccharide (TSP), was carried out. Both cationic and anionic derivatives of TSP were prepared, characterized, and their degree of substitution was determined. Films prepared using derivatives were evaluated for their swelling potential and bioadhesive strength. The carboxymethyl and sulfate derivatives were showed higher swelling index and required higher force of detachment compared to native gum thus, indicating that introduction of carboxymethyl, sulfate, and amine groups in TSP can increase the bioadhesive strength. The results suggested that anionic and cationic derivatives can be employed for formulation of bioadhesive drug delivery systems.