Induction of Endoplasmic Reticulum Stress Genes,<i>BiP</i>and<i>Chop</i>, in Genetic and Environmental Models of Retinal Degeneration

Abstract

Our study reveals surprising increases in BiP and to a lesser degree Chop in retinal degenerations arising from diverse causes. We propose that manipulation of ER stress responses may be helpful in treating many environmental and heritable forms of retinal degeneration.