Concepedia

A Thioester Ligation Approach to Amphipathic Bicyclic Peptide Library

Ying Sun, Gui-Shen Lu, James P. Tam

Organic Letters · 2001 · 21 citations · 24 references

DOI

Concepts

Abstract

An efficient approach to synthesize an amphipathic bicyclic peptide library from unprotected peptides is demonstrated through an on-resin intramolecular thioester ligation and an off-resin DMSO-mediated disulfide formation.

References

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