New Type of Mono-tetrahydrofuran Ring Acetogenins from <i>Goniothalamus donnaiensis</i>

Abstract

A new type of Annonaceous acetogenin was isolated from the roots of Goniothalamus donnaiensis . The structures of two epimeric pairs, donnaienin A ( 1 ) and 34- epi -donnaienin A ( 1 ‘), and donnaienin B ( 2 ) and 34- epi -donnaienin B ( 2‘ ), characterized by the presence of a γ-(hydroxymethyl) γ-lactone moiety, were elucidated by spectroscopic analysis and chemical derivatization. Four known mono-THF acetogenins murisolin, isoannonacin, and a mixture of annonacin and goniothalamicin were also isolated.