Copper-mediated synthesis of N-fused heterocycles via Csp–S coupling reaction and 5-endo-dig cyclization sequence

Abstract

A novel method was developed for the preparation of N-fused heterocycles via a Csp–S coupling reaction and a sequence of 5-endo-dig cyclization. This method involves the reaction of –NHC(S)NH-containing compounds and alkynes in the presence of CuCl and N,N′-dicyclohexylimidazolium chloride.