OESTROGENIC, ANTI-OESTROGENIC AND ANTIFERTILITY ACTIVITIES OF VARIOUS COMPOUNDS

Abstract

Summary. The activities of twelve steroids and fifteen non-steroids are reported for tests in mice of oestrogenic and anti-oestrogenic activity (vaginal smear) and antifertility activity (administration in early pregnancy). No steroid, with the possible exception of 17α-(2'-methallyl)-9β,10α-androst-4-en-17-ol-3-one (SAP 104), had antifertility effects not explained by its oestrogenic activity. Among the non-steroids, mesoα,α'-dimethyl-4,4'-dihydroxybibenzyl (meso-dma), 1 - [p- (2-diethylaminoethoxy) phenyl]-2-(p-methoxyphenyl)-1-phenylethane (MRL 37) and possibly 1-[p-(2-diethylaminoethoxy)phenyl]-2-(p-methoxyphenyl)1-phenylethanol (MER 25) may have antifertility effects unrelated or incompletely related to oestrogenic activity and possibly related to antioestrogenic activity.