Philosophical Transactions of the Royal Society of London Series A Physical and Engineering Sciences · 1990 · 27 citations · 10 references
Natural SciencesBiophysicsDevelopmental BiologyBiomedical ImagingDiagnostic ImagingMagnetic Resonance BiophysicsCellular ImagingDiffusion ImagingMagnetic Resonance ImagingMagnetic Resonance Molecular ImagingMagnetic Resonance SpectroscopyMedical ImagingBandwidthMicroscopic ImagingMicroscopyMicroscopy ImagingMolecular DiffusionPulse SequencesSignal AttenuationSignal-to-noise Ratio
Abstract Recent advances in NMR microscopy based on fundamental physical parameters and experimental factors are discussed. We consider fundamental resolution limits due to molecular diffusion and the experimental system bandwidth, as well as practical resolution limits arising from poor signal-to-noise ratio due to small imaging voxel size and finite line broadening due to signal attenuation brought about by diffusion. Several microscopic imaging pulse sequences are presented and applied to elucidating cellular imaging problems such as the cell lineage patterns in Xenopus laevis embryos. Experimental results obtained with 7.0 T NMR microscopy system are presented.
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Fates of the blastomeres of the 32-cell-stage Xenopus embryo
Sally A. Moody · Developmental Biology · 1987 · 385 citations
Nuclear magnetic resonance imaging of a single cell
James B. Aguayo, Stephen J. Blackband, Joseph S. Schoeniger et al. · Nature · 1986 · 330 citations