Reverse‐mode<scp>NCX</scp>current in mouse airway smooth muscle:<scp><scp>N</scp></scp>a⁺and voltage dependence, contributions to<scp><scp>C</scp></scp>a²⁺influx and contraction, and altered expression in a model of allergen‐induced hyperresponsiveness

Abstract

Reverse-mode NCX activity leads to a physiologically relevant increase in [Ca(2+) ] even under control conditions, and this may be exaggerated in allergen-induced AHR and asthma.