Publication | Closed Access
Enantioselective Friedel−Crafts Alkylation of Pyrroles Catalyzed by PYBOX-DIPH-Zn(II) Complexes
78
Citations
34
References
2009
Year
Chemical EngineeringEngineeringEnantioselective Friedel−crafts AlkylationEnantioselective Friedel-crafts AlkylationOrganic ChemistrySubstantial Substrate ScopeCatalysisStereoselective SynthesisChemistryOrganometallic CatalysisAsymmetric CatalysisEnantioselective SynthesisChiral Pybox-diph-zn
A highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoylpyridine N-oxides catalyzed by chiral PYBOX-DIPH-Zn(II) complexes has been developed. The catalyst offers substantial substrate scope and furnished alkylated pyrroles in excellent yields (up to 99%) and enantioselectivities (up to >99% ee).
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