Highly Stereoselective Synthesis of 2,5-Disubstituted 3-Vinylidene Tetetrahydrofurans via Prins-Type Cyclization

Abstract

[reaction: see text]. A novel synthetic methodology for 2,5-disubstituted tetrahydrofurans having an allenyl group at the 3-position via Prins-type cyclization was developed. The reaction led to excellent selectivity and moderate to high yields.