DONOR T CELLS ARE NOT REQUIRED FOR INDUCTION OF ALLOGRAFT TOLERANCE IN MICE TREATED WITH ANTILYMPHOCYTE SERUM, RAPAMYCIN, AND DONOR BONE MARROW CELLS1

Abstract

Donor type T cells and T cell chimerism are not required for induction of allograft tolerance by the antilymphocyte serum/rapamycin/donor BMC-infusion protocol. Donor B cells also do not participate in tolerance induction. Thus, infusion of T cell-depleted BMC in conjunction with conventional immunosuppressive regimens will be a simple, safe, and effective way to induce allograft tolerance in clinical organ transplantation.